Shravan Kumar Kannan
The broader research focus of the Badovinac lab is to understand the mechanisms that govern the CD4 and CD8 T cell responses to infection and immunization. The emphasis is on exploring the pathways that are involved in antigen specific T cell homeostasis in vivo, and understanding how the manipulation of these pathways can be used to facilitate the generation and maintenance of productive memory T cell responses in health and disease, using mouse model systems and human samples.
My research here is specifically geared towards understanding CD4 T cell mediated immune regulation during total body irradiation and sepsis induced Immune dysfunction using mouse models.
Publications
C.Y. Kim, S.K. Kannan, V.P. Badovinac & T.S. Griffith (2024). Protocol for inducing monomicrobial sepsis in mice with uropathogenic E. coli. STAR Protocols, 5(3), 103206. (doi: 10.1016/j.xpro.2024.103206)
S.K. Kannan, C.Y. Kim, M. Heidarian, R.R. Berton, I.J. Jensen, T.S. Griffith, & V.P. Badovinac (2024). Mouse models of sepsis. Current Protocols, 4(3), e997. (doi: 10.1002/cpz1.997)
M. Heidarian, I.J. Jensen, S.K. Kannan, L.L. Pewe, M. Hassert, S.R. Park, H.H. Xue, J.T. Harty, V.P. Badovinac (2023) Sublethal whole-body irradiation induces permanent loss and dysfunction in pathogen-specific circulating memory CD8 T cell populations. Proc. Nat. Acad. Sci. 120(27), e2302785120. (doi:10.1073/pnas.2302785120)
Honors and Awards
Graduate College Post-Comprehensive Exam Research Fellowship (2023)
AAI Young Investigator Award at the Autumn Immunology Conference (2023)