Vladimir Badovinac


Our long-term interest lies in elucidating the mechanisms that govern CD8 T cell responses after infection and/or immunization. We are interested in exploring the pathways that are involved in Ag-specific CD8 T cell homeostasis in vivo and exploring how the manipulation of these pathways can be used to facilitate the generation and maintenance of productive memory CD8 T cell responses in health and disease.

We also study sepsis, a devastating & poorly controlled systemic infection, to define a sepsis-induced state of immunoparalysis and develop treatments to restore immunity in sepsis survivors.

Our main (and everchanging) research goals are to:

  • Determine the factors that influence generation, maintenance and function of memory CD8 T cells
  • Characterize CD8 T cells responding to multiple rounds of antigenic stimulations
  • Establish relevant experimental models to study antigen-experienced CD8 T cells in vivo;
  • Investigate the alterations in T cell-mediated immunity that occur after sepsis
  • Define sepsis-induced state of immunoparalysis and explore treatments to restore immunity in sepsis survivors.
Research areas
  • Cancer immunology
  • Adaptive immunity
  • Immune cell activation and interactions
  • Host-pathogen interactions
  • Pathogenesis
  • T cell Biology
  • Vaccines, Drugs, and Biologics
  • Cytokines/Chemokines
  • Immune memory
  • Sepsis
  • Human immunology
Vladimir Badovinac
Contact Information

1020 ML
United States


1023 ML
United States

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