Sara Hamilton

Advisor
John Harty
Primary and secondary CD8+T cell responses after Listeria monocytogenes infection or peptide-coated dendritic cell immunization

My current research is concerned with examining the role of bacterial antigen compartmental ligation in the level of recombinant epitope produced during the course of an infection

Hamilton SE, Badovinac VP, Khanolkar A, Harty JT. Listeriolysin O-deficient Listeria monocytogenes as a vaccine delivery vehicle: antigen-specific CD8 T cell priming and protective immunity. J Immunol. 2006 Sep 15;177(6):4012-20. PubMed PMID: 16951364.

Tvinnereim AR, Hamilton SE, Harty JT. Neutrophil involvement in cross-priming CD8+ T cell responses to bacterial antigens. J Immunol. 2004 Aug 1;173(3):1994-2002. PubMed PMID: 15265934.

Hamilton SE, Porter BB, Messingham KA, Badovinac VP, Harty JT. MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response. Nat Immunol. 2004 Feb;5(2):159-68. Epub 2004 Jan 25. PubMed PMID: 14745446.

Badovinac VP, Messingham KA, Hamilton SE, Harty JT. Regulation of CD8+ T cells undergoing primary and secondary responses to infection in the same host. J Immunol. 2003 May 15;170(10):4933-42. PubMed PMID: 12734336.

Badovinac VP, Hamilton SE, Harty JT. Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice. Immunity. 2003 Apr;18(4):463-74. PubMed PMID: 12705850.

Hamilton SE, Harty JT. Quantitation of CD8+ T cell expansion, memory, and protective immunity after immunization with peptide-coated dendritic cells. J Immunol. 2002 Nov 1;169(9):4936-44. PubMed PMID: 12391206.

Tvinnereim AR, Hamilton SE, Harty JT. CD8(+)-T-cell response to secreted and nonsecreted antigens delivered by recombinant Listeria monocytogenes during secondary infection. Infect Immun. 2002 Jan;70(1):153-62. PubMed PMID: 11748177;PubMed Central PMCID: PMC127606.

Hamilton SE, Tvinnereim AR, Harty JT. Listeria monocytogenes infection overcomes the requirement for CD40 ligand in exogenous antigen presentation to CD8(+) T cells. J Immunol. 2001 Nov 15;167(10):5603-9. PubMed PMID: 11698431.

Honors and Awards

  • HHMI - Knox summer research fellowship
  • Honors in Biochemistry, cum laude (Knox College),
  • Sigma Xi
  • Autumn Immunology Conference, 11/98
Assistant Professor
Department of Laboratory Medicine & Pathology
University of Minnesota
Sara Hamilton