The Badovinac lab studies both CD8 T cell responses in infections/immunizations and immune responses in septic hosts. My current research focus is on evaluating corticosterone responses during sepsis and their downstream role in modulating disease. Also, I am using murine hepatitis virus (MHV-1) to define the extent to which murine corona virus infection of susceptible mouse strains evokes sepsis-like disease.

Publications

Silva EE, Moioffer SJ, Hassert M, Berton RR, Smith MG, van de Wall S, Meyerholz DK, Griffith TS, Harty JT, Badovinac VP. Defining Parameters That Modulate Susceptibility and Protection to Respiratory Murine Coronavirus MHV1 Infection. J Immunol. 2024 Feb 15;212(4):563-575. doi: 10.4049/jimmunol.2300434. PMID: 38149923; PMCID: PMC10872354.

Barrios EL, Mazer MB, McGonagill PW, Bergmann CB, Goodman MD, Gould RW, Rao M, Polcz VE, Davis RJ, Del Toro DE, Dirain ML, Dram A, Hale LO, Heidarian M, Kim CY, Kucaba TA, Lanz JP, McCray AE, Meszaros S, Miles S, Nelson CR, Rocha IL, Silva EE, Ungaro RF, Walton AH, Xu J, Zeumer-Spataro L, Drewry AM, Liang M, Bible LE, Loftus TJ, Turnbull IR, Efron PA, Remy KE, Brakenridge SC, Badovinac VP, Griffith TS, Moldawer LL, Hotchkiss RS, Caldwell CC. Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot. JCI Insight. 2024 Jan 23;9(2):e175785. doi: 10.1172/jci.insight.175785. PMID: 38100268; PMCID: PMC10906237.

Silva EE, Skon-Hegg C, Badovinac VP, Griffith TS. The Calm after the Storm: Implications of Sepsis Immunoparalysis on Host Immunity. J Immunol. 2023 Sep 1;211(5):711-719. doi: 10.4049/jimmunol.2300171. PMID: 37603859; PMCID: PMC10449360.

Jensen IJ, McGonagill PW, Berton RR, Wagner BA, Silva EE, Buettner GR, Griffith TS, Badovinac VP. Prolonged Reactive Oxygen Species Production following Septic Insult. Immunohorizons. 2021 Jun 18;5(6):477-488. doi: 10.4049/immunohorizons.2100027. PMID: 34145054; PMCID: PMC8686528.