My laboratory has two major research interests: Neuroimmunology and Mucosal Immunology.  In Neuroimmunology, we focus on the immunobiology of oligodendrocyte progenitor cells (OPCs) in Multiple Sclerosis by using animal models; we also study the immune function of LRRK2 in the pathogenesis of Parkinson’s disease.  In Mucosal Immunology, we focus on the role of LRRK2-mediated innate immunity in host defense and intestinal inflammation including inflammasome activation; In addition, we study LKB1-driven gut microbiota dysfunction (dysbiosis) in the pathogenesis of gastrointestinal polyposis and tumorigenesis. To integrate this two research interests, our long-term goal is to understand how gut-brain axis modulates the pathogenesis of neurodegenerative diseases.  Our research will open novel avenues for the therapy of related diseases.