Prajwal Gurung, PhD
We are interested in investigating the role of PRRs in regulating immunity and maintaining homeostasis.
PRRs sense pathogen/damage-associated molecular patterns to protect and maintain cellular homeostasis. Nod like receptors (NLRs), a family of cytoplasmic sensors, recognize pathogen/damage-associated molecules within the cell. Several studies including ours have shown that these NLRs play a central role not only in viral, bacterial and parasitic infections, but also in autoinflammatory and autoimmune diseases. The research goals of our lab are to investigate how these NLRs regulate innate and adaptive immune responses. To unravel the underlying mechanisms governing NLRs and their function, we use bacterial, parasitic and viral infection of mice, as well as autoinflammatory disease models. Current research focus of the lab includes: 1) Investigating the role of cytoplasmic PRRs in anti-leishmanial immunity. 2) Exploring the molecular mechanisms underlying autoinflammatory diseases using a mouse model of neutrophilic dermatosis.
- Innate immunity
- Adaptive immunity
- Cell signaling/Signal transduction
- Gene expression and regulation
- Pathogen recognition
- Immune cell activation and interactions
- Host-pathogen interactions
- Immune memory