Li Wu, PhD
Defining the mechanisms of HIV replication and understanding the role of immune cells and host factors that participate in the process are essential for developing effective strategies to eradicate HIV infection. Dr. Wu’s lab studies the molecular and cellular mechanisms of HIV replication, virus interaction with host factors and anti-HIV innate immunity. The lab focuses on the molecular and cellular mechanisms underlying HIV-1 restriction by the host protein SAMHD1, which is the first identified mammalian dNTP triphosphohydrolase (dNTPase). We also investigate functional significance and the mechanisms by which N6-methyladenosine (m6A) modification of HIV-1 RNA regulates viral gene expression in immune cells. Our basic studies can lay the foundation to facilitate the development of more effective interventions against HIV infection.
- Innate immunity
- Host-pathogen interactions
- Vaccines, Drugs, and Biologics