Our research focuses on the role of neutrophils in the regulation of inflammation in the lung. In particular, we are interested in the Triggering Receptor Expressed on Myeloid cells 1 (TREM-1), an innate immune receptor expressed on neutrophils that functions as an amplifier of lung inflammation and controls neutrophil migration into the airspace. These sentinel leukocytes direct the early innate immune response to danger signals in the airspace. Our studies address mechanistically how neutrophil migration into the airspace is regulated in the setting of diverse stimuli including pathogens, diesel exhaust, reperfusion injury, and metastatic cancer cells. The long term goal of this research is to identify the molecular pathways utilized during TREM-1 dependent migration into the airspace and leverage this information in the development of therapeutic tools to modulate neutrophil responses in the lung.