Joy McMullan (Crowther)

Pulmonary Surfactant Protein A Interactions with Human Macrophages: Binding and Trafficking of SP-A, and Alteration of the Respiratory Burst
Biography

Henning LN, Azad AK, Parsa KV, Crowther JE, Tridandapani S, Schlesinger LS. Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J Immunol. 2008 Jun 15;180(12):7847-58. PubMed PMID: 18523248; PubMed Central PMCID: PMC2562757.

Hall-Stoodley L, Watts G, Crowther JE, Balagopal A, Torrelles JB, Robison-Cox J, Bargatze RF, Harmsen AG, Crouch EC, Schlesinger LS. Mycobacterium tuberculosis binding to human surfactant proteins A and D, fibronectin, and small airway epithelial cells under shear conditions. Infect Immun. 2006 Jun;74(6):3587-96. PubMed PMID: 16714591; PubMed Central PMCID: PMC1479241.

Crowther JE, Schlesinger LS. Endocytic pathway for surfactant protein A in human macrophages: binding, clathrin-mediated uptake, and trafficking through the endolysosomal pathway. Am J Physiol Lung Cell Mol Physiol. 2006 Feb;290(2):L334-42. Epub 2005 Sep 16. PubMed PMID: 16169899.

Beharka AA, Crowther JE, McCormack FX, Denning GM, Lees J, Tibesar E Schlesinger LS. Pulmonary surfactant protein A activates a phosphatidylinositol 3-kinase/calcium signal transduction pathway in human macrophages: participation in the up-regulation of mannose receptor activity. J Immunol. 2005 Aug 15;175(4):2227-36. PubMed PMID: 16081790.

Crowther JE, Kutala VK, Kuppusamy P, Ferguson JS, Beharka AA, Zweier JL, McCormack FX, Schlesinger LS. Pulmonary surfactant protein a inhibits macrophage reactive oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity. J Immunol. 2004 Jun 1;172(11):6866-74. PubMed PMID: 15153505.

Freelance Biomedical Writer and Editor
Joy McMullan (Crowther)