A well-coordinated immune response is characterized by the rapid initiation of inflammation in response to an immune challenge. However, this response is sustained only until the insult or injury is contained; at that point, the inflammatory response is terminated or resolved. Thus, the controlled and appropriate resolution of inflammation is an essential feature of the innate immune response. Previous studies from our lab have shown that the metalloprotease tumor-necrosis factor-α-converting enzyme (TACE) controls the release of soluble tumor necrosis factor TNF-α and activation of epidermal growth factor receptor (EGFR)-signaling in an iRhom2-dependent manner. My current interest lies in deciphering the role of iRhom2 in innate cell-mediated immunity and its potential contribution to associated diseases.

Skurski, J., Penniman, C.M., Geesala, R., Dixit, G., Pulipati, P., Bhardwaj, G., Meyerholz, D.K., Issuree, P.D., O'Neill, B.T. and Maretzky, T., 2020. Loss of iRhom2 accelerates fat gain and insulin resistance in diet-induced obesity despite reduced adipose tissue inflammation. Metabolism, p.154194.

Geesala R, Schanz W, Biggs M, Dixit G, Skurski J, Gurung P, Meyerholz DK, Elliott D, Issuree PD, Maretzky T. Loss of RHBDF2 results in an early-onset spontaneous murine colitis. J Leukoc Biol. 2019 Jan 29. doi:10.1002/JLB.4A0718-283RR. [Epub ahead of print] PubMed PMID: 30694569.