Nurbek Mambetsariev

Advisor
Mechanisms of TRAF3 Mediated Regulation of B Cell Survival
Biography

Role of TRAF3 in Multiple Myeloma and B-cell Homeostasis

TRAF3 is an important regulator of B-cell activation and homeostasis. Inhibition of TRAF3 expression in mice leads to B-cell hyperplasia. In addition, mutations in the TRAF3 gene leading to the loss of function have been observed in multiple myeloma. Our goal is to further elucidate the mechanism behind TRAF3-mediated B-cell signaling and identify its potential role in pathogenesis of multiple myeloma.

Whillock AL, Mambetsariev N, Lin WW, Stunz LL, Bishop GA. Author Correction: TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells. Sci Rep. 2019 Nov 20;9(1):17502. doi: 10.1038/s41598-019-53669-2. PubMed PMID: 31745166.

Whillock AL, Mambetsariev N, Lin WW, Stunz LL, Bishop GA. TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells. Sci Rep. 2019 Sep 9;9(1):12884. doi: 10.1038/s41598-019-49390-9. Erratum in: Sci Rep. 2019 Nov 20;9(1):17502. PubMed PMID: 31501481; PubMed Central PMCID: PMC6733949.

Bangalore-Prakash P, Stunz LL, Mambetsariev N, Whillock AL, Hostager BS, Bishop GA. The oncogenic membrane protein LMP1 sequesters TRAF3 in B-cell lymphoma cells to produce functional TRAF3 deficiency. Blood Adv. 2017 Dec 18;1(27):2712-2723. doi: 10.1182/bloodadvances.2017009670. eCollection 2017 Dec 26. PubMed PMID: 29296923; PubMed Central PMCID: PMC5745131.

Mambetsariev N, Lin WW, Wallis AM, Stunz LL, Bishop GA. TRAF3 deficiency promotes metabolic reprogramming in B cells. Sci Rep. 2016 Oct 18;6:35349. doi:10.1038/srep35349. PubMed PMID: 27752131.

Mambetsariev N, Lin WW, Stunz LL, Hanson BM, Hildebrand JM, Bishop GA. Nuclear TRAF3 is a negative regulator of CREB in B cells. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1032-7. doi: 10.1073/pnas.1514586113. Epub 2016 Jan 11. PubMed PMID: 26755589; PubMed Central PMCID: PMC4743771.

Resident
Internal Medicine PSTP
McGraw Medical Center of Northwestern University
Nurbek Mambetsariev