Investigating the roles of inflammatory cytokines in regulating the CD8+ T cell memory differentiation program and exploiting cross-presentation as a potential approach to rapidly generate protective CD8+ T cells.

Gorman JV, Starbeck-Miller G, Pham NL, Traver GL, Rothman PB, Harty JT, Colgan JD. Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection. J Immunol. 2014 Apr 1;192(7):3133-42. doi: 10.4049/jimmunol.1302290. Epub 2014 Feb 24. PubMed PMID: 24567532; PubMed Central PMCID: PMC3965639.

Pham NL, Badovinac VP, Harty JT. Epitope specificity of memory CD8+ T cells dictates vaccination-induced mortality in LCMV-infected perforin-deficient mice. Eur J Immunol. 2012 Jun;42(6):1488-99. doi: 10.1002/eji.201142263. PubMed PMID:22678903.

Kashiwada M, Pham NL, Pewe LL, Harty JT, Rothman PB. NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development. Blood. 2011 Jun 9;117(23):6193-7. Epub 2011 Apr 7. PubMed PMID: 21474667; PubMed Central PMCID:PMC3122942.

Pham NL, Badovinac VP, Harty JT. Differential role of "Signal 3" inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo. Front Immunol. 2011;2:4. Epub 2011 Feb 11. PubMed PMID: 22566795; PubMed Central PMCID:PMC3342074.

Pham NL, Pewe LL, Fleenor CJ, Langlois RA, Legge KL, Badovinac VP, Harty JT. Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12198-203. Epub 2010 Jun 21. PubMed PMID:20616089; PubMed Central PMCID: PMC2901444.

Khanolkar A, Fulton RB, Epping LL, Pham NL, Tifrea D, Varga SM, Harty JT. T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts. J Immunol. 2010 Jul 15;185(2):1132-41. Epub 2010 Jun 16. PubMed PMID: 20554960; PubMed Central PMCID:PMC2897948.

Rai D, Pham NL, Harty JT, Badovinac VP. Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts. J Immunol. 2009 Dec 15;183(12):7672-81. Epub . PubMed PMID: 19933864; PubMed Central PMCID: PMC2808048.

Pham NL, Badovinac VP, Harty JT. A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigen-driven proliferation. J Immunol. 2009 Aug 15;183(4):2337-48. Epub 2009 Jul 27. PubMed PMID: 19635915; PubMed Central PMCID:PMC2786780.

Wirth TC, Pham NL, Harty JT, Badovinac VP. High initial frequency of TCR-transgenic CD8 T cells alters inflammation and pathogen clearance without affecting memory T cell function. Mol Immunol. 2009 Nov;47(1):71-8. Epub 2009 Feb 5. PubMed PMID: 19195704.