Siao-Yi Wang

Advisor
Interactions Between Complement and Cellular Mediated Mechanisms in Antibody Therapy of Cancer
Biography

Veeramani S, Wang SY, Dahle C, Blackwell S, Jacobus L, Knutson T, Button A, Link BK, Weiner GJ. Rituximab infusion induces NK activation in lymphoma patients with the high-affinity CD16 polymorphism. Blood. 2011 Sep 22;118(12):3347-9. Epub 2011 Jul 18. PubMed PMID: 21768303 PMCID:PMC3179401.

Wang SY, Veeramani S, Racila E, Cagley J, Fritzinger DC, Vogel CW, St John W, Weiner GJ. Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model. Blood. 2009 Dec 17;114(26):5322-30. Epub 2009 Oct 5. PubMed PMID: 19805620; PubMed Central PMCID:PMC2796137.

Wang SY, Weiner G. Complement and cellular cytotoxicity in antibody therapy of cancer. Expert Opin Biol Ther. 2008 Jun;8(6):759-68. Review. PubMed PMID:18476787.

Wang SY, Racila E, Taylor RP, Weiner GJ. NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement. Blood. 2008 Feb 1;111(3):1456-63. Epub 2007 Nov 16. PubMed PMID: 18024795; PubMed Central PMCID: PMC2214766.

Bowles JA, Wang SY, Link BK, Allan B, Beuerlein G, Campbell MA, Marquis D, Ondek B, Wooldridge JE, Smith BJ, Breitmeyer JB, Weiner GJ. Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab. Blood. 2006 Oct 15;108(8):2648-54. Epub 2006 Jul 6. PubMed PMID: 16825493; PubMed Central PMCID: PMC1895597.

Assistant Professor
Hematology/Oncology
Loyola University Medical Center
Siao-Yi Wang