The Role Of Pulmonary Dendritic Cells In Regulating The Antigen-Specific CD8 T Cell Response Following Influenza Virus Infection

My research examines the role of dendritic cells (DC) in the lungs following influenza virus infections. DC are known to be required in the lymph nodes to initiate programmed activation, proliferation and differentiation of virus-specific CD8 T cells. However, DC are continually recruited to the lungs following influenza virus infection, but their role in the regulation of innate and adaptive immune responses therein remains unknown. Our lab determined a novel role for DC in the lungs in promoting influenza virus specific CD8 T cell immunity through direct MHC I dependent interactions. My research continues to examine the mechanism behind pulmonary DC mediated regulation of adaptive CD8 T cell responses in the lungs.

Hemann EA, McGill JL, Legge KL. Chronic ethanol exposure selectively inhibits the influenza-specific CD8 T cell response during influenza a virus infection. Alcohol Clin Exp Res. 2014 Sep;38(9):2403-13. doi: 10.1111/acer.12522. Epub 2014 Aug 26. PubMed PMID: 25160044; PubMed Central PMCID: PMC4461571.

Case AJ, McGill JL, Tygrett LT, Shirasawa T, Spitz DR, Waldschmidt TJ, Legge KL, Domann FE. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med. 2011 Feb 1;50(3):448-58. doi: 10.1016/j.freeradbiomed. 2010.11.025. Epub 2010 Dec 2. PubMed PMID: 21130157;PubMed Central PMCID: PMC3026081.

VanoOsten Anderson R, McGill J, Legge KL. Quantification of the frequency and multiplicity of infection of respiratory- and lymph node-resident dendritic cells during influenza virus infection. PLoS One. 2010 Sep 23;5(9):e12902. doi:10.1371/journal.pone.0012902. PubMed PMID: 20886117; PubMed Central PMCID:PMC2944834.

McGill J, Van Rooijen N, Legge KL. IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection. J Exp Med. 2010 Mar 15;207(3):521-34. doi: 10.1084/jem.20091711. Epub 2010 Mar 8. PubMed PMID: 20212069; PubMed Central PMCID: PMC2839152.

McGill J, Legge KL. Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection. J Immunol. 2009 Oct 1;183(7):4177-81. doi: 10.4049/jimmunol.0901109. PubMed PMID: 19767567;PubMed Central PMCID: PMC2762786.

McGill J, Heusel JW, Legge KL. Innate immune control and regulation of influenza virus infections. J Leukoc Biol. 2009 Oct;86(4):803-12. doi:10.1189/jlb.0509368. Epub 2009 Jul 30. Review. PubMed PMID: 19643736; PubMed Central PMCID: PMC2752015.

McGill J, Meyerholz DK, Edsen-Moore M, Young B, Coleman RA, Schlueter AJ, Waldschmidt TJ, Cook RT, Legge KL. Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections. J Immunol. 2009 Jun 15;182(12):7803-8. doi: 10.4049/jimmunol.0803881. PubMed PMID: 19494304; PubMed Central PMCID: PMC2692078.

McGill J, Van Rooijen N, Legge KL. Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs. J Exp Med. 2008 Jul 7;205(7):1635-46. doi: 10.1084/jem.20080314. PubMed PMID: 18591411; PubMed Central PMCID: PMC2442641.

Meyerholz DK, Edsen-Moore M, McGill J, Coleman RA, Cook RT, Legge KL. Chronic alcohol consumption increases the severity of murine influenza virus infections. J Immunol. 2008 Jul 1;181(1):641-8. PubMed PMID: 18566431; PubMed Central PMCID: PMC2504736.

McGill J, Legge KL (2008). Continued proliferation of influenza-specific T cells in the lungs during the early stages of influenza virus infections. Options for the Control of Influenza VI. 162.(non peer reviewed therefore no PMCID), 2008.

Meyerholz DK, Edsen-Moore M, McGill J, Coleman RA, Cook RT, Legge KL. Response to Comment on “Chronic alcohol consumption increases the severity of murine influenza virus infections.” The Journal of Immunology, 181:5813, 2008.