Christopher Thompson

The Role of Macrophage Sphingosine Kinase 1 in Phagocytosis, Phagosome Maturation, and Mycobacterial Infection
Biography

Kusner DJ, Thompson CR, Melrose NA, Pitson SM, Obeid LM, Iyer SS. The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. J Biol Chem. 2007 Aug 10;282(32):23147-62. Epub 2007 May 22. Erratum in: J Biol Chem. 2008 Feb 29;283(9):5972. PubMed PMID: 17519232.

Iyer SS, Agrawal RS, Thompson CR, Thompson S, Barton JA, Kusner DJ. Phospholipase D1 regulates phagocyte adhesion. J Immunol. 2006 Mar 15;176(6):3686-96. PubMed PMID: 16517737.

Thompson CR, Iyer SS, Melrose N, VanOosten R, Johnson K, Pitson SM, Obeid LM, Kusner DJ. Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis. J Immunol. 2005 Mar 15;174(6):3551-61. PubMed PMID: 15749892.

Malik ZA, Thompson CR, Hashimi S, Porter B, Iyer SS, Kusner DJ. Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase. J Immunol. 2003 Mar 15;170(6):2811-5. PubMed PMID: 12626530.

Associate Professor
Biology
Loyola University - Maryland
Christopher Thompson