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Currently I am involved in two projects. The first involves studying how inflammation affects CD8 T cell memory kinetics. Dr. John Harty's lab has shown that the rate at which CD8 T cells acquire memory characteristics can be manipulated by controlling inflammation. I am currently using mouse genome-wide ChIP-Sequencing along with mouse genome-wide microarray analysis to uncover how inflammation influences the progression by which CD8 T cells attain memory characteristics at the molecular level. For the second project, I am investigating the role of Fc gamma receptors on the surface of antigen-experienced T cells. Much speculation surrounds the idea of Fc gamma receptors residing on the surface of T cells; however, we have recently observed a dramatic increase of their presence on activated CD8 T cells at the level of transcription and cell surface expression following in vivo immunization. Within the scope of this project, I plan to elucidate the unknown role Fc gamma receptors play on the surface of antigen-experienced T cells.
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