Kathryn Trandem |
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| Research Interests | |
| Mice infected with hepatitis virus, strain JHM (JHMV), develop a chronic demyelinating disease with similarities to multiple sclerosis. The disease is largely immunopathological, with demyelination occurring during the course of virus clearance. We seek to investigate the role of regulatory T cells in JHMV-induced demyelination using two complementary experiments with adoptive transfer of regulatory T cells (CD4+foxp3+) and/or JHMV-immune splenocytes to C57BL/6 (immunocompetent) and Rag1-/- (immunodeficient) recipients. Additionally, we are investigating IL-10 with the ultimate goal of understanding the relationship between regulatory T cells and IL-10-producing cells in virus-induced demyelination. This research will contribute to our understanding of the immune system's role in mediating demyelination through a virus-induced murine multiple sclerosis model. Our goal is that this knowledge will lead to better treatment and therapies for persons suffering from this disabling disease. | |
| Publications | |
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Anghelina, D., Zhao, J., Trandem , K., Perlman, S. Role of regulatory T cells in coronavirus-induced acute encephalitis. Virology. 2009 Mar 15;385(2):358-67. Epub 2009 Jan 11. PubMed PMID: 19141357; PubMed Central PMCID: PMC2684864.
Butler, N., Pewe, L., Trandem , K., Perlman, S. HCoV-OC43-induced encephalitis is in part immune-mediated. Adv Exp Med Biol. 2006;581:531-4. No abstract available. PMID: 17037592 [PubMed - indexed for MEDLINE] Butler, N., Pewe, L., Trandem , K., Perlman, S. Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated. Virology. 2006 Apr 10;347(2):410-21. Epub 2006 Jan 18. PMID: 16413043 [PubMed - indexed for MEDLINE] |
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