Jodi McGill |
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| Research Interests | |
| My research examines the role of dendritic cells (DC) in the lungs following influenza virus infections. DC are known to be required in the lymph nodes to initiate programmed activation, proliferation and differentiation of virus-specific CD8 T cells. However, DC are continually recruited to the lungs following influenza virus infection, but their role in the regulation of innate and adaptive immune responses therein remains unknown. Our lab determined a novel role for DC in the lungs in promoting influenza virus specific CD8 T cell immunity through direct MHC I dependent interactions. My research continues to examine the mechanism behind pulmonary DC mediated regulation of adaptive CD8 T cell responses in the lungs. | |
| Publications | |
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McGill , J., Meyerholz, D.K., Edsen-Moore, M., Young, B., Coleman, R.A., Schlueter, A.J., Waldschmidt, T.J., Cook, R.T., Legge, K.L. Fetal exposure to ethanol has long-term
effects on the severity of influenza virus infections. J Immunol. 2009 Jun 15;182(12):7803-8. PubMed PMID: 19494304; PubMed Central PMCID: PMC2692078.
McGill , J., Van Rooijen, N., Legge, K.L. Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs. J Exp Med. 2008 Jul 7;205(7):1635-46. PMID: 18591411 [PubMed - indexed for MEDLINE] Meyerholz, D.K., Edsen-Moore, M., McGill , J., Coleman, R.A., Cook, R.T., Legge, K.L. Chronic alcohol consumption increases the severity of murine influenza virus infections. J Immunol. 2008 Jul 1;181(1):641-8. PMID: 18566431 [PubMed - indexed for MEDLINE] cGill, J., Legge, K.L. Contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection. Submitted: JI Cutting Edge |
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