Jessica Haverkamp |
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| Research Interests | |
| Our lab is interested in studying prostate inflammation (prostatitis) and the immune cells involved in regulating this disease. To study prostate inflammation, our lab has developed a novel mouse model called the Prostate Ovalbumin Transgenic (POET) mouse. Using this model, we can induce prostatitis by transferring Ovalbumin specific T cells into POET mice and study regulation of inflammation in an antigen specific T cell driven immune response. Using the POET model, our lab has determined that large numbers of myeloid derived suppressor cells (MDSC) accumulate in inflamed prostates. MDSC are involved in dampening T cell driven tumor immunity, and emerging evidence suggests their function is strongly linked to their regulatory function. Therefore the goal of my thesis is to identify the role of MDSC in prostatitis and to evaluate the mechanism(s) they use to suppress T cell function during acute prostatitis. | |
| Publications | |
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Haverkamp , J., Charbonneau, B., Ratliff, T.L. Prostate inflammation and its potential impact on prostate cancer: a current review. J Immunol. 2007 Aug 1 2008;179(3):1648-58. PMID: 17955503 [PubMed - indexed for MEDLINE]
Haverkamp , J., Crist, S.,Elzey, B., Ratliff, T.L. Regulatory activity of myeloid derived suppressor cells is restricted to inflammatory site. Submitted, 2009. |
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