Kathryn Trandem

Trandem
  • Mt. Holyoke College
  • B.A., Chemistry, Wesleyan University
Date left program: 
10/15/2010
Degree received: 
M.D./Ph.D.
Date Ph.D. awarded: 
May, 2012
Research

Mice infected with hepatitis virus, strain JHM (JHMV), develop a chronic demyelinating disease with similarities to multiple sclerosis. The disease is largely immunopathological, with demyelination occurring during the course of virus clearance. We seek to investigate the role of regulatory T cells in JHMV-induced demyelination using two complementary experiments with adoptive transfer of regulatory T cells (CD4+foxp3+) and/or JHMV-immune splenocytes to C57BL/6 (immunocompetent) and Rag1-/- (immunodeficient) recipients. Additionally, we are investigating IL-10 with the ultimate goal of understanding the relationship between regulatory T cells and IL-10-producing cells in virus-induced demyelination. This research will contribute to our understanding of the immune system's role in mediating demyelination through a virus-induced murine multiple sclerosis model. Our goal is that this knowledge will lead to better treatment and therapies for persons suffering from this disabling disease.

Publications

Zhao J, Zhao J, Fett C, Trandem K, Fleming E, Perlman S. IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med. 2011 Aug 1;208(8):1571-7. Epub 2011 Jul 11. PubMed PMID: 21746812; PubMed Central PMCID: PMC3149215.

Trandem K, Jin Q, Weiss KA, James BR, Zhao J, Perlman S. Virally expressed interleukin-10 ameliorates acute encephalomyelitis and chronic demyelination in coronavirus-infected mice. J Virol. 2011 Jul;85(14):6822-31. Epub 2011 May 18. PubMed PMID: 21593179; PubMed Central PMCID: PMC3126551.

Trandem K, Zhao J, Fleming E, Perlman S. Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis. J Immunol. 2011 Mar 15;186(6):3642-52. Epub 2011 Feb 11. PubMed PMID: 21317392; PubMed Central PMCID: PMC3063297.

Trandem K, Anghelina D, Zhao J, Perlman S. Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus. J Immunol. 2010 Apr 15;184(8):4391-400. Epub 2010 Mar 5. PubMed PMID: 20208000; PubMed Central PMCID: PMC2851486.

Anghelina D, Zhao J, Trandem K, Perlman S. Role of regulatory T cells in coronavirus-induced acute encephalitis. Virology. 2009 Mar 15;385(2):358-67. Epub 2009 Jan 11. PubMed PMID: 19141357; PubMed Central PMCID: PMC2684864.

Butler N, Pewe L, Trandem K, Perlman S. HCoV-OC43-induced encephalitis is in part immune-mediated. Adv Exp Med Biol. 2006;581:531-4. PubMed PMID: 17037592.

Butler N, Pewe L, Trandem K, Perlman S. Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated. Virology. 2006 Apr 10;347(2):410-21. Epub 2006 Jan 18. PubMed PMID: 16413043.

Post-program
Resident
Urology
Baylor College of Medicine