My research focuses on the Epstein-Barr virus encoded CD40 mimic Latent membrane protein 1 (LMP1). Specifically, I am interested in how the TRAF binding site, through regulation of the TNF receptor associated factor (TRAF) adaptor signaling molecules, TRAF3&5, regulates some but not all LMP1 signaling outcomes.
Arcipowski KM, Stunz LL, Graham JP, Kraus ZJ, Vanden Bush TJ, Bishop GA. Molecular mechanisms of TNFR-associated factor 6 (TRAF6) utilization by the oncogenic viral mimic of CD40, latent membrane protein 1 (LMP1). J Biol Chem. 2011 Mar 25;286(12):9948-55. Epub 2011 Jan 24. PubMed PMID: 21262968; PubMed Central PMCID: PMC3060549.
Graham JP, Arcipowski KM, Bishop GA. Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1. Immunol Rev. 2010 Sep;237(1):226-48. Review. PubMed PMID: 20727039.
Graham JP, Moore CR, Bishop GA. Roles of the TRAF2/3 binding site in differential B cell signaling by CD40 and its viral oncogenic mimic, LMP1. J Immunol. 2009 Sep 1;183(5):2966-73. Epub 2009 Aug 10. PubMed PMID: 19667091; PubMed Central PMCID: PMC2747101.