My research focuses on the Epstein-Barr virus encoded CD40 mimic Latent membrane protein 1 (LMP1). Specifically, I am interested in how the TRAF binding site, through regulation of the TNF receptor associated factor (TRAF) adaptor signaling molecules, TRAF3&5, regulates some but not all LMP1 signaling outcomes.
Bankert KC, Oxley KL, Smith SM, Graham JP, de Boer M, Thewissen M, Simons PJ, Bishop GA. Induction of an altered CD40 signaling complex by an antagonistic human monoclonal antibody to CD40. J Immunol. 2015 May 1;194(9):4319-27. doi:10.4049/jimmunol.1402903. Epub 2015 Mar 20. PubMed PMID: 25795759.
Arcipowski KM, Stunz LL, Graham JP, Kraus ZJ, Vanden Bush TJ, Bishop GA. Molecular mechanisms of TNFR-associated factor 6 (TRAF6) utilization by the oncogenic viral mimic of CD40, latent membrane protein 1 (LMP1). J Biol Chem. 2011 Mar 25;286(12):9948-55. Epub 2011 Jan 24. PubMed PMID: 21262968; PubMed Central PMCID: PMC3060549.
Graham JP, Arcipowski KM, Bishop GA. Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1. Immunol Rev. 2010 Sep;237(1):226-48. Review. PubMed PMID: 20727039.
Graham JP, Moore CR, Bishop GA. Roles of the TRAF2/3 binding site in differential B cell signaling by CD40 and its viral oncogenic mimic, LMP1. J Immunol. 2009 Sep 1;183(5):2966-73. Epub 2009 Aug 10. PubMed PMID: 19667091; PubMed Central PMCID: PMC2747101.