Colin Thalhofer

thalhofer
  • B.S., Biology, Gonzaga University
Date left program: 
04/22/2011
Degree received: 
Ph.D.
Date Ph.D. awarded: 
May, 2011
Research

Host immune responses to Leishmania chagasi infection

Advisor: 
Mary Wilson, M.D.

When humans are infected with Leishmania chagasi the outcome of infection is primarily determined by the host immune response. Individuals that clear the infection successfully generate a Th1 immune response against the parasite, where as enhanced parasite survival and disease progression is seen in individuals that fail to mount a Th1 response. The host immune factors that augment or inhibit the generation of a L. chagasi-specific Th1 response are not well understood. My research involves developing an animal model using luciferase-expressing parasites to visualize the L. chagasi infection in vivo. Using this model and other tools, I am beginning to study the host immune factors that regulate L. chagasi infection during parasite dissemination, survival, and clearance.

Publications

Thalhofer CJ, Chen Y, Sudan B, Love-Homan L, Wilson ME. Leukocytes infiltrate the skin and draining lymph nodes in response to the protozoan Leishmania infantum chagasi. Infect Immun. 2011 Jan;79(1):108-17. Epub 2010 Oct 11. PubMed PMID: 20937764; PubMed Central PMCID: PMC3019875.

Thalhofer CJ, Graff JW, Love-Homan L, Hickerson SM, Craft N, Beverley SM, Wilson ME. In vivo imaging of transgenic Leishmania parasites in a live host. J Vis Exp. 2010 Jul 27;(41). Pii: 1980. doi: 10.3791/1980. PubMed PMID: 20689512.

Chang HK, Thalhofer C, Duerkop BA, Mehling JS, Verma S, Gollob KJ, Almeida R, Wilson ME. Oxidant generation by single infected monocytes after short-term fluorescence labeling of a protozoan parasite. Infect Immun. 2007 Feb;75(2):1017-24. Epub 2006 Nov 21. PubMed PMID: 17118986; PubMed Central PMCID:PMC1828521.

Post-program
Postdoctoral Research Scientist
AgonOx