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| Generation and manipulation of memory CD8 T cell responses | ||||||
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CD8 T cells are important in defense against viruses, intracellular bacteria and protozoan pathogens and are also potentially important in defense against malignancy. They recognize and respond to pathogen-encoded peptides displayed by MHC class I molecules on infected cells or on antigen (Ag)-presenting cells (APC) that have acquired these peptides through crosspresentation pathways. Activated CD8 T cells manifest an array of antimicrobial effector pathways and molecules, which eliminate infected cells (cytolysis) or recruit and activate other immune cells (cytokines). Thus, stimulation of pathogen-specific CD8 T cell responses is an important goal of vaccination.
Our main goals are: To establish relevant experimental models to study antigen-experienced CD8 T cells in vivo; To determine the factors that influence generation, maintenance and function of memory CD8 T cells; To characterize CD8 T cells responding to multiple rounds of antigenic stimulations; To define homeostasis of tumor (self)-specific CD8 T cells. |
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| Selected Publications | ||||||
| Click Here for a Complete List of Articles | ||||||
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Badovinac V.P., Messingham, K.A., Jabbari, A., Haring, J.S. and Harty, J.T. Accelerated CD8+ T cell-memory and prime-boost response after dendritic-cell vaccination. Nature Medicine 11, 748-756, 2005.
Badovinac V.P., Haring, J.S. and Harty, J.T. Initial TCR-transgenic precursor frequency dictates critical aspects of the CD8 T cell response to infection. Immunity 26, 827-841, 2007. Badovinac V.P. and Harty, J.T. Manipulating the rate of memory CD8 T cell generation after acute infection. The Journal of Immunology 179, 53-63, 2007. Harty, J.T. and Badovinac V.P. Shaping and reshaping CD8 T cell memory. Nature Reviews Immunology 8, 107-119, 2008. |
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| Department/Program Affiliations |
| Pathology |
| Biosciences |
| Immunology |