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| Innate and adaptive immune reponses in asthma | ||||||
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1) Role of microbes and pathogens, their products, and analogues (such as CpG oligodeoxynucleotides) in the modulation of the airway inflammatory response in a murine model of asthma. We have previously demonstrated that administration of CpG at the time of sensitization to allergen (ovalbumin) in a murine model of asthma can prevent the development of eosinophilic inflammation and bronchial hyperreactivity. We are now in the process of studying (in vitro and in vivo) the mechanisms through which CpG ODN can accomplish these results and also examining how administration of CpG ODN (with and without specific immunotherapy) can lead to treatment of established inflammatory responses.
2) Regulatory cells in antigen-mediated asthma. We are developing murine models to evaluate the regulatory functions of dendritic cells , T-cells, and other important innate immune cells in the response to atopic airway inflammation and its modulation. 3) Mind-brain-body responses in asthmatic responses. |
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| Selected Publications | ||||||
| Click Here for a Complete List of Articles | ||||||
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Shah, A.S., Ben-Shahar, Y., Moninger, T.O., Kline J.N. and Welsh, M.J. Motile cilia of human airway epithelia are chemosensory. Science. 325(5944):1131-4, 2009.
Kulhankova, K., George, C.L., Kline J.N., Snyder, J.M., Darling, M., Field, E.H. and Thorne, P.S. Early-life co-administration of cockroach allergen and endotoxin augments pulmonary and systemic responses. Clin Exp Allergy. 39(7):1069-79, 2009. Vermeer, P.D., Denker, J., Estin, M., Moninger, T.O., Keshavjee, S., Karp, P., Kline J.N. and Zabner, J. MMP9 modulates tight junction integrity and cell viability in human airway epithelia. Am J Physiol Lung Cell Mol Physiol. 296(5):L751-62, 2009. Fonseca, D.E. and Kline J.N. Use of CpG oligonucleotides in treatment of asthma and allergic disease. Adv Drug Deliv Rev. 61(3):256-62, 2009. |
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| Department/Program Affiliations |
| Internal Medicine |
| Biosciences |
| Immunology |