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| T cell responses to infection | ||||||
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In my laboratory we combine cellular and molecular approaches to dissect T cell mediated resistance to pathogens. Specifically, we use murine infection with Listeria monocytogenes, a bacterial pathogen or lymphocytic choriomeningitis virus, as model systems to understand the biology of CD8+ T cell mediated immunity to infection. We are also studying the factors that determine CD8 T cell mediated immunity from liver-stage malaria infection.
Current projects involve: Regulation of memory T cell development Effector mechanisms of CD8 T cells in whole animal models of infectious disease. T cell homeostasis in response to infection. T cell mediated immunopathology after virus infection. CD8 T cell immunity from live-stage malaria. |
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| Selected Publications | ||||||
| Click Here for a Complete List of Articles | ||||||
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Jabbari, A. and Harty J.T. Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype. Journal of Experimental Medicine. 203: 919-932, 2006.
Badovinac, V.P., Haring, J.S. and Harty J.T. Initial TCR-transgenic precursor frequency dictates critical aspects of the CD8 T cell response to infection. Immunity. 26: 827-841, 2007. Schmidt, N.W., Podyminogin, R.L., Butler, N.S., Tucker, B.J., Reyes-Sandoval, A., Hutchings, C.L., Moore, A.C., Gilbert, S.C., Hill, A.V., Bartholomay, L.C. and Harty J.T. Memory CD8 T cell responses exceeding a large, but definable threshold provide long-term immunity to malaria. Proceedings of the National Academy of Sciences: 105:14017-14022, 2008. Badovinac, V.P. and Harty J.T. Shaping and Reshaping CD8 T cell memory. Nature Reviews Immunology. 8:107-119, 2008. |
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| Department/Program Affiliations |
| Microbiology |
| Biosciences |
| Immunology |
| MSTP |